The MAO inhibitors are somewhat more dangerous drugs than other antidepressants when taken in excessive amounts -- far more so than newer drugs
Their discovery was serendipitous; the anti-tuberculosis agent, iproniazid
It is both an SSRI and a serotonin 1α (5HT-1α) partial agonist (like the anti-anxiety medication buspirone), so it is classified as a multimodal serotonergic agent
John’s wort at Antidepressants, including MAOIs, have a mandated “boxed warning,” also called a black box warning, from the U
Irreversible MAOIs, such as phenelzine, isocarboxazid, and tranylcypromine, have a rapid absorption and clearance rate, with pharmacokinetic half-lives ranging from 1
Tricyclic and related antidepressants block the re-uptake of both serotonin and noradrenaline, although to different extents
Monoamine oxidase inhibitors (MAOIs) are an extremely strong class of antidepressants that treat depression by preventing the breakdown of the brain chemicals serotonin, dopamine, and Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed
Tramadol (an atypical opioid painkiller with norepinephrine reuptake blocking effects)
• Phenylzine (Nardil) 15-90 mg (divided into TID dosing for acute) • Tranylcypromine (Parnate) 10-60 mg (divided into BID dosing for acute) • Selegiline (Eldepryl) • Isocarboxazid (Marplan) • Moclobemide (Manerix) 300-600mg, doses of 600-900 mg can be used, but Study this MAOIs mnemonic and other NCLEX mnemonics with Pixorize
Antidepressants are used to alter the concentration of neurotransmitters in the brain that is responsible for the depressed affect (feelings in response to the environment, whether positive and pleasant or negative and unpleasant)
Monoamine oxidase inhibitors, or MAOIs, were one of the earliest antidepressants in the United States, being first made available to consumers in the 1950s
Irreversible MAOIs, such as phenelzine, isocarboxazid, and tranylcypromine, have a rapid absorption and clearance rate, with pharmacokinetic half-lives ranging from 1
Tertiary sources warn that the combination of MAO-B inhibitors and SSRIs
No reports involved the administration of methylene blue by other routes (such as oral tablets or local tissue injection)